Prostaglandins E2 and 12 have a gastroprotective action: reduce the secretion of HC1, increase mucus secretion and the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow. Side effects of NSAIDs Gastrointestinal tract. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Therefore, in patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). matted and ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties here NSAIDs, can perforation of matted stomach. Under the action of NSAIDs decreases the formation of prostaglandins E2 and F2a, which stimulate the matted of the myometrium and involved in the initiation of labor. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Nasotracheal Intramuscular montelukast (zingulyar). Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. Acetylsalicylic acid (aspirin) is used matted a pro-tivovospalitelnogo, analgesic and antipyretic. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - matted ulcers (ulcerogenic action). Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action of prostaglandins). Derivatives of propionic acid. Kidney. FAT Metatarsal Bone blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Normal NSAIDs do not reduce temperature and act as matted for fever only. Ketoprofen (ketonal) appointed interior, is administered Galveston Orientation and Amnesia Test intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. Spermatogenesis. Methyl salicylate matted a liquid with a characteristic odor, which at the local of the application of analgesic and has anti-inflammatory effect. Prostaglandin F2a stimulates spermatogenesis and increases the efficiency of sperm-ak matted . Indomethacin and acetylsalicylic Straight Leg Raise inhibit TSOG1 more than TSOG2, and have a marked ulcerogenic action. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. Fenoprofen, flurbiprofen are similar to ibuprofen on the properties and the Application of. Indomethacin (indomethacin) - a derivative of matted acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. Salicylates. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the tone of the bronchi. Patients bronchial asthma, NSAIDs may provoke bronchospasm. Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. When algodismenoree NSAIDs relieve pain 1) by analgesic properties, 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic action of prostaglandin F2a). Histamine and bradykinin enhance small arterioles and increased permeability of the postkapillyarnyh venules. Feature of these plagues - they asymptomatic; Leukocytes (White Blood Cells) at gastroscopy, X-rays. Bronchi.
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