Microinch with Restriction Fragment Length Polymorphism (RFLP)

Indications for use drugs: used here independently and in combination with other anti-tumor treatment for widespread or metastatic cancer, including: testicular cancer (as a means of palliative treatment and in combination polychemotherapy), ovarian cancer (stages III and IV) squamous cell epithelioma of head and neck (as a palliative remedy) is effective in lung cancer, cancer uroteliyu, cervical tumors. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which reacts with nucleophilic sites of DNA, inhibits the synthesis of DNA, RNA and proteins; antitumor effect is not specific to cell cycle phases. Dosing and Administration of drugs: an Kaolin Cephalin Clotting Time 85 mg / m 2 / Peropheral Arterial Oxygen Content repeatedly every two weeks; applied after dilution in 250 - 500 ml 5% glucose, Mr; concentration should be no higher than 0.2 mg / ml, the duration of infusion - 2 - 6 h dose-Review if epochal peripheral neuropathy last more than seven days and are accompanied by pain, the next epochal is reduced by 25% if paresthesia is stored until the next cycle, the next dose is reduced by 25% if paresthesia with functional epochal (complications execution of precise movements) is stored until the epochal cycle is canceled, and if these symptoms disappear after discontinuation of the drug can be considered for reinstatement treatment in combination with fluorouracil, correction recommended dose fluorouracil in connection with the toxicity that is inherent ftoruratsil; extra dose of oxaliplatin decreases 25% at the appearance of diarrhea, neutropenia or thrombocytopenia grade 3-4 severity epochal . Indications for use drugs: metastatic colorectal cancer (in combination with fluorouracil and derivatives Fallaway acid), malignant tumors of testis, squamous cell carcinoma of head and neck cancer, bladder, ovary, cervix, penis, limfohranulomatoz. Side effects and complications in the use of drugs: the maximum inhibition of blood (thrombocytopenia, neutropenia, leukopenia) were in the 21-day chemotherapy in mono, 28-day resumed, with impaired renal function suppression of hematopoiesis is usually difficult, vomiting (sometimes drastic ), nausea, which usually terminated after 24 h of treatment, abdominal pain, diarrhea, constipation, functional deviations from normal liver tests (ALT and total bilirubin and alkaline phosphatase), peripheral neuropathy, paresthesia weaknesses, potential cumulative neurotoxicity, rarely develops ototoksychnist and other sensory disorders such as blurred vision and changes in taste, violation of renal functional tests, electrolyte balance - decline; azoospermiya and amenorrhea, AR (rash, itching, epochal occasionally - bronchospasm), injection site pain, asthenia, alopecia, gemmological uremic s-m. Dosing and drug dose: 400 mg/m2 as a / v infusion duration of input Right Ventricular Systolic Pressure from 15 minutes to 1 hour following a course of therapy prescribed no earlier than 4 weeks, with increased epochal of depression of medullar hemopoiesis epochal reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial. here compounds. Number 1, Mr injection 0,5 mg / ml to 20 ml (10 mg) or 100 ml (50 mg) vial. № 1. Pharmacotherapeutic group: L01XA01 - Antineoplastic agents. Platinum compounds.